Spectroscopic Evidence for the Unusual Stereochemical Configuration of an Eedosome-Specific Lipid

摘要

Glycerophospholipds are essential components of cell membranes from archaea to bacteria and mammals. These lipids feature either an sn-3 or sn-1 glycerophosphate (GP) backbone. in archaea, glycerophospholipids are exclusively phos-phorylated at the sn-1 position. in contrast, in bacteria and eukaryotic cells phosphorylation is restricted to the sn-3 position. It has been proposed that chiral discrimination caused the phase separation of sn-1- and .sn-3-phosphorylated lipids, leading up to the segregation of archaea and bacteria. However, the mammalian lipid bis(monoacylglycero)phos-phate (1, BMP) has been reported to be the only exception, featuring an sn-1 GP backbone.