Core-Structure-Oriented Asymmetric Organocatalytic Substitution of 3-Hydroxyoxindoles: Application in the Enantioselective Total Synthesis of (+)-Folicanthine

摘要

Cyclotryptamine alkaloids constitute a large family of natural products (Figure 1) which show fascinating biological activities.For example, (+)-chaetocin not only shows antibacte- rial and cytostatic activity, but is also a potent inhibitor of a lysine-specific histone me thyltransferase. The compound WIN 64821, first isolated from Aspergillus sp., is a potent competitive substance P antagonist with respect to human ncurokinin-1 and the cholecystokinin B receptor. Moreover, other members of the cyclotryptamine alkaloid family have also been found to exhibit important biological and pharmaceutical activities.