Mild Rhodium(III)-Catalyzecl C-H Activation and Intermolecular Annulation with Allenes

摘要

The carbometalation reaction of allenes provides efficient access to highly versatile and reactive π-allyl metal species (Scheme 1). These intermediates can undergo Tsuji-Trost-type substitutions in the presence of external nucleophiles to yield the allyhc functionalized products. Intramolecular versions of this reaction lead to interesting carbo-or heterocyclic skeletons, frequently found in pharmaceuticals and materials.