Mesoporous Silica Nanoparticles End-Capped with Collagen: Redox-Responsive Nanoreservoirs for Targeted Drug Delivery

摘要

The construction of stimuli-responsive controlled-release systems for targeted drug delivery to specific cells is of crucial importance for the development of both fundamental science and clinical medicine. Surface-functionalized, end-capped mesoporous silica nanoparticles (MSNs) are ideal stimuli-responsive carriers for controlled drug and/or gene delivery, because of their unique mesoporous structures, large surface areas, tunable pore sizes, and good biocompatibility, both in vitro and in vivo. End-capping the mesopores of MSNs for efficient drug delivery, especially anticancer drugs that have serious side effects, has been frequently investigated. Various components have been employed to construct end-capped MSNs for controlled drug release; such MSNs include pseudorotaxanes,inorganic Au nanoparticles, Fe3O4,and CdS. Recently, azobenzene, lactose, a specific polyclonal antibody for sulfathiazole, and β-cyclodextrin were reported to act as molecular caps for MSNs. Surface-functionalized MSNs were also used for targeted drug delivery. Nevertheless, none of these reports combined end-capped MSNs and cell-specific targeting for stimuli-responsive controlled drug release.