Self-Resistance to an Antitumor Antibiotic: A DNA Glycosylase Triggers the Base-Excision Repair System in Yatakemycin Biosynthesis

摘要

Most of the antibiotics in clinical use to treat human disease are natural products produced by microorganisms. A general hypothesis is that antibiotic-resistance genes and mechanisms have co-evolved with antibiotic biosynthesis as a self-protection scheme.Nature has evolved three major ways for avoidance of suicide in antibiotic-producing microbes: antibiotic modification, target-protecting enzymes, and export pumps. However, other resistance mechanisms have yet to be discovered, especially for the highly toxic molecules that interrupt basic biological processes (for example DNA, protein, cell-wall biosynthesis).