Re-engineering Electrochemical Biosensors To Narrow or Extend Their Useful Dynamic Range

摘要

The use of electrode-immobilized biomolecules, such as proteins and nucleic acids, is a common feature among many emerging biotechnological applications. For example, the specificity, affinity, and versatility of biomolecular recognition has been exploited for the development of a wide range of electrochemical biosensors that show promise for the detection of many clinically and industrially important analytes.Such "bioelectronic interfaces" also form the basis of biofuel cells and molecular logic gates, applications that have attracted significant recent attention. Interest in the applications of surface-electrode-bound biomolecular systems is thus rapidly growing.