Residual Dipolar Couplings as a Powerful Tool for Constitutional Analysis: The Unexpected Formation of Tricyclic Compounds

摘要

Anisotropic NMR parameters in partially aligned samples, such as residual dipolar couplings (RDCs), residual chemical shift anisotropy (RCSA), and residual quadrupolar couplings (RQCs), contain valuable structural information. As has been shown on a multitude of examples, RDCs are a useful tool to determine the configuration and the conformation of small to medium-sized organic molecules. Herein, we now add a further facet by demonstrating the power of RDCs in the analysis of the constitution of an unknown small molecule.