Enantioselective Ficini Reaction: Ruthenium/PNNP-Catalyzed [2+2] Cycloaddition of Ynamides with Cyclic Enones

摘要

Recent synthetic advances have turned ynamides into broadly available substrates whose reactivity can be finely tuned. In particular, the cross-coupling of amides with alkynyl bromides gives broad access to widely substituted ynamides. Thus, the last few years have witnessed a surge of their use as nitrogen-containing building blocks in organic chemistry that undergo addition at the α or β positions, oxidative or reductive coupling, oxidation, ring-closing metathesis, cyclo-isomerization, and cycloaddition reactions.