Synthesis of the Backbone Cyclic Peptide Sunflower Trypsin Inhibitor-1 Promoted by the Induced Peptidyl-tRNA Drop-off

摘要

Ribosomes occasionally stall on mRNA in the middle of translation and one of the mechanisms to rescue the ribosome involves the drop-off of peptidyl-tRNA from the P site of the stalled ribosome. Although peptidyl-tRNA drop-off can, in principle, occur at any position during the translational elongations, the slower rate of the termination step relative to the elongation step can result in the stalling of the