Scaffolding Catalysts: Highly Enaetioselective Desymmetrization Reactions

摘要

The use of reversible covalent bonding is a common design feature in synthetic catalysts. For most synthetic catalysts, reversible covalent bonding is used to form a reactive intermediate thereby affording an enhanced rate of reaction (e.g. enamine, iminium, and N-heterocyclic carbene catalysis). A less developed area of reversible covalent bonding catalysis uses this bonding to transiently tether reagents (Figure 1).