Total Chemical Synthesis of Biologically Active Vascular Endothelial Growth Factor

摘要

Vascular endothelial growth factor (VEGF), also known as VEGF-A, is the principal endothelial-cell-specific mitogen that induces embryonic and somatic angiogenesis. VEGF also plays an important role in tumor angiogenesis and in proliferative retinopathy. In animal models of pathological conditions, it has been shown that over-expression of VEGF stimulates the generation of new blood vessels, and thus accelerates tumor growth and the progression of the neo-vascular form of age-related macular degeneration.