Aplysqualenol A Binds to the Light Chain of Dynein Type 1 (DYNLL1)

摘要

Natural products continue to serve as a hotbed for cancer chemotherapy, providing vital leads, probes, and clinical entries. The advance of spectroscopic methods and analytical techniques has led our understanding into the dynamic yet complex structural diversity of marine secondary metabolites. Even given the expanse of this molecular diversity, we have only identified the biomolecular targets of a small subset of the known natural products, and many of those that have been identified arise owing to the fact that they share common targets (examples include actin or microtubules). The fact remains that we have only begun to understand the myriad of biological pathways engaged by secondary metabolites.