Dendrimer-Mediated Multivalent Binding for the Enhanced Capture of Tumor Cells

摘要

Multivalent binding, the simultaneous binding of multiple ligands to multiple receptors, has played a central role in a number of pathological processes, including the attachment of viral, parasitic, mycoplasmal, and bacterial pathogens. These biological activities have been extensively investigated to promote targeting of specific cell types, and biological multivalent inhibitors have yielded significant increases in binding avidities by one to nine orders of magnitude. In particular, nanoscale poly(amidoamine) (PAMAM) dendrim-ers have been reported to be an excellent mediator for facilitated multivalent effect owing to their capability to preorganize/orient ligands and the easy deformability of the polymer chains.