Highly Enantioselective Synthesis of Axially Chiral Biarylphosphonates: Asymmetric Suzuki-Miyaura Coupling Using High-Molecular-Weight, Helically Chiral Polyquinoxaline-Based Phosphines

摘要

Asymmetric synthesis has developed rapidly with the exploration of chiral molecular scaffolds for use as chiral ligands, reagents, and auxiliaries. Some molecular frameworks such as 1,1'-binaphthyl are widely recognized as privileged scaffolds for chiral sciences and technologies, including not only asymmetric synthesis, but also chiral recognition and separa-tion. In addition to those small-molecule-based chiral scaffolds for asymmetric synthesis, recent efforts have also been devoted to the development of macromolecular chiral scaffolds for asymmetric synthesis.