Highly N~2-Selective Palladium-Catalyzed Arylation of 1,2,3-Triazoles

摘要

N-Substituted 1,2,3-triazoles have found widespread applications in material science and medicinal chemistry. Because of the importance of this structural motif, many practical synthetic methods have been developed. Among them, the Huisgen azide-alkyne dipolar cycloaddition (AAC) is perhaps the most commonly utilized method for the synthesis of N~1-substituted 1,2,3-triazoles. In particular, recent developments in copper-and ruthenium-catalyzed AAC reactions have provided a general and regioselective access to 1,4- and 1,5-substituted 1,2,3-triazoles, respectively.