Palladium-Catalyzed C—C Bond Formation To Construct 1,4-Diketones under Mild Conditions

摘要

Carbon-carbon bond formation is the central transformation in synthetic organic chemistry. Although there are a number of strategies to construct C—C bonds, nucleophilic substitution is perhaps the oldest and most widely used of these methods. These transformations typically involve primary alkyl halides or tosylates as electrophiles to couple with a variety of different nucleophiles. Direct substitution of a leaving group at a C(sp~2) center is not possible, while substitution is well known for secondary alkyl (C(sp~3)) positions even though this can still prove problematic.