Nickel-Catalyzed Animation of Aryl Sulfamates

摘要

Carbon-nitrogen bonds are ubiquitous in medicinal agents and natural products. Transition metal-catalyzed amination reactions, pioneered by Buchwald and Hartwig, are amongst the most powerful methods available for accessing these motifs. Copper- and palladium-mediated aminations of aryl halides and triflates are now well-established, and examples of mesylate and tosylate aminations have been reported. Most recent efforts have focused on the amination of classically "inert" phenolic derivatives (i.e., arylmethyl ethers and aryl pivalate esters), which could potentially be used in multistep synthesis. With the aim of assembling polysubstituted aryl amines, motifs commonly encountered in drug scaffolds, naturally occurring small molecules, pesticides, ligands for catalysis, and materials chemistry, we sought to uncover a versatile class of phenol-derived substrates that could undergo transition metal-catalyzed amination.