Tuning DNA Stability To Achieve Turnover in Template for an Enzymatic Ligation Reaction

摘要

In the last decade, DNA-based systems have been developed that are capable of performing sophisticated functions initiated by molecular recognition. Key examples are the DNA walkers where directional motion or load pick-up, transfer, and release are achieved with molecular and spatial selectivity. Attempts to develop autonomous DNA self-replicating systems, however, without specific sequence requirements, have in recent years lagged behind.