Gephyronic Acid, a Missing Link between Polyketide Inhibitors of Eukaryotic Protein Synthesis (Part I): Structural Revision and Stereochemical Assignment of Gephyronic Acid

摘要

Culture supernatants of Archangium gephyra strain Ar 3895 demonstrated antibiotic activity, leading to the isolation of a novel polyketide, gephyronic acid (1), as a separable mixture of keto and hemiketal isomers Their structures (Scheme 1) were included in a single publication describing their isolation and biological activity, but spectroscopic data were not included.