Regidselective Rhodium(II)-Catalyzed Hydroaminations of Propargylguanidmes

摘要

Cyclic and polycyclic guanidinium ion natural products have been shown to modulate a variety of important biological processes and their activities are often reliant on the unique hydrogen bond donor-acceptor topologies that these substructures display. While most synthetic methods to prepare guanidines rely on the addition of an amine (guanylation) of an activated thiourea or urea, alternative methodologies that generates peripheral C—N bonds from an intact guani-dine nucleus have proven powerful for the preparation of polycyclic guanidine natural products.