Electrochemical Allylation Reactions of Simple I mines in Aqueous Solution Mediated by Nanoscale Zinc Architectures

摘要

Addition of allylmetal reagents to C=N double bonds is one of the most important and straightforward methods to afford homoallylic amines, which are useful building blocks for many biologically active compounds and nitrogen-containing natural products. In recent years, organic reactions that can be performed in aqueous media have attracted great interest because of significant environmental and economical advantages, especially for the Barbier-type reactions in aqueous media.However, owing to the lower electrophilicity of simple imines and their instability in water, most of the previously reported metal-mediated aqueous allylation reactions were focused on the use of special imines, such as sulfonimines, tosyl or aryl hydrazones, and glyoxylic oxime ethers.