Synthesis of Atropisomerically Defined, Highly Substituted Biaryl Scaffolds through Catalytic Enantioselective Bromination and Regioselective Cross-Coupling

摘要

The challenge of atropisomer-selective syntheses is often manifested in drug discovery projects, and also in the synthesis of materials with interesting optical properties. With respect to the former, numerous small-molecule ligands for proteins and enzyme inhibitors exist as conformational racemates, with low barriers to atropisomerization (Figure 1).