Highly Diastereo- and Enantioselective Synthesis of 5-Substituted 3-PyrroIidin-2-ones: Vinylogous Michael Addition under Multifunctional Catalysis

摘要

5-Substituted 3-pyrrolidin-2-ones and their structural analogues have been found as crucial fragments in a number of complex natural and non-natural compounds, such as the lycorane-type alkaloids, the stemona family, and the large family of indole alkaloids including haplophytine, vindoline, and the strychnos family of alkaloids (Scheme 1).