Gold(I)-Catalyzed Cycloisomerization of 1,6-Diynes: Synthesis of 2,3-Disubstituted 3-Pyrroline Derivatives

摘要

Homogeneous catalysis mediated by gold complexes has received considerable attention in recent years. Among these interesting reactions, gold-catalyzed cycloisomerization of 1,6-enynes and l,6-diynes is one of the most important strategies for the construction of functionalized cyclic structures (Scheme 1). In the context of our ongoing efforts to develop gold-catalyzed tandem reactions, we realized that the gold-catalyzed cascade transformation of 1,6-diynes to abnormal five-membered cycloadducts has been less explored (Scheme 1).