Chiral Bronstcd Acid Catalyzed Pinacol Rearrangement

摘要

The Br0nsted acid catalyzed conversion of cyclic or acyclic vicinal diols to aldehydes or ketones through dehydration and subsequent [1,2]-alkyl, [1,2]-aryl, or hydride shift is a truly venerable reaction known as the pinacol rearrangement. Because of the likelihood of multiple carbocation formation during the reaction, the regioselectivity can vary, and widespread usage has suffered.