Dynamic and Programmable DNA-Templated Boronic Ester Formation

摘要

The Darwinian evolution of biomolecules is described as a continuous process of mutation, selection, and amplification. According to a widely accepted hypothesis, the spontaneous prebiotic generation of nucleic acid oligomers evolved through a variety of possible combinations of information building blocks. Over the past few decades, several research groups have investigated various chemical systems able to promote nonenzymatic oligonucleotide ligation.Among the hypotheses investigated, it has been postulated that the early-life selection process might have taken advantage of reversible backbone linkages, which provided a means to repair themselves or transform in response to their environment. Indeed, reversible chemical connections in biomolecular species enable the development of adaptive dynamic systems capable of responding to external factors, such as temperature, the pH value, or molecular-recognition events.