Divergent Outcomes of Carbene Transfer Reactions from Dirhodium-and Copper-Based Catalysts Separately or In Combination

摘要

That a reaction pathway can be redirected to a different product by changing a reactant or reaction conditions is well known and widely practiced. Such processes are referred to as "divergent", and this term is broadly applied to methodology, synthesis, reactivity and selectivity, among others. However, processes in which the same reactant(s) form different products in synthetically meaningful yields by application of different catalysts are rare. We and others have reported exceptionally efficient catalyst-dependent processes that occur with the same diazo substrates to form structurally different compounds.