Flexible Gold-Catalyzed Regioselective Oxidative Difunctionalization of Unactivated Alkenes

摘要

Diols, diamines, and aminoalcohols are ubiquitous functionalities in complex organic molecules. From the seminal work of Sharpless and co-workers on the intermolecular osmium-catalyzed asymmetric dihydroxylation and aminohydroxyla-tion of alkenes, the development of alternative methods to access these privileged motifs has become a priority for synthetic organic chemists. In recent years, palladium catalysts in combination with PhI(OAc)2 as oxidant have been successfully used in the aminooxygenation and diamination of unactivated alkenes both intra- and intermolecularly.