Fast and Efficient Fluorination of Small Molecules by SF_4~(2+)

摘要

As a result of fluorine's high electronegativity, fluorination a can have a dramatic effect on molecular properties. Nowhere is this perturbation more important than for organic compounds, where fluorination can impart substantial metabolic stability to prospective pharmaceutically active species. However, because of their stability and inertness, facile synthesis of C—F bonds still provides a considerable challenge for chemists.