A Concise Total Synthesis of (+)-Neopeltolide

摘要

(+)-Neopeltolide (1) is a marine macrolide that belongs to the family Neopeltidae, and was isolated from a deep-water sponge collected off the northwest coast of Jamaica by Wright et al . Neopeltolide exhibits highly potent in vitro antiproliferative activity against several cancer cell lines with nanomolar IC_(50) values (IC_(50) = 1.2, 5.1, and 0.56 nmol L~(-1) against the A-549 human lung adenocarcinoma, the NCI-ADR-RES human ovarian sarcoma, and the P388 murine leukemia cells, respectively) as well as potent antifungal activity against pathogenic yeast Candida albicans. Kozmin and co-workers reported that neopeltolide targets cytochrome bc1 complex and may inhibit mitochondrial ATP synthesis. The complex molecular architecture coupled with the intriguing biological activity of 1 have spurred the interest of the synthetic community. A number of total syntheses of 1, including the studies from our research group, have been reported.