Remote C—H Functionalization: Using the N—O Moiety as an Atom-Economical Tether to Obtain 1,5-and the Rare 1,7-C—H Insertions

摘要

Contemporary organic synthesis faces the demands of improving its efficiency by redox and atom economy, including achieving superior chemo-, regio-, and stereoselectivity. Consequently, there has been great interest in the transformations of inert C—H bonds, as these open up new avenues in synthesis. Significant progress has been made towards site-selective C—H-insertion reactions, but this field still presents major challenges owing to the ubiquitous nature of C—H bonds in organic molecules. The regioselec-tivity of C—H insertions is governed by electronic, steric, and conformational factors.