Iron-Catalyzed Direct Arylation of Unactivated Arenes with Aryl Halides

摘要

Cross-coupling reactions used to construct biaryl compounds mainly involve Ar~1X as an electrophile and Ar~2M as a nucleophile. Recently, C-H bond activation has been used, where Ar~2H served as the nucleophile to react with Ar~1X (direct arylation of arenes). This strategy efficiently avoids the disposal of stoichiometric amounts of metal waste generated from the organometallic reagent, ArM, in the traditional coupling manner. Various transition metals have been reported as efficient catalysts for this transformation, for example, Pd, Rh, Ru, Ir, Cu, and other transition metals.