One-Pot Synthesis of Benzimidazoles by Simultaneous Photocatalytic and Catalytic Reactions on Pt@TiO2 Nanoparticles

摘要

Benzimidazole and its derivatives occupy pivotal positions in the synthesis of natural products and pharmaceutical materials. These compounds have been studied extensively because of their biological activities as bactericides, anticarcino-gens, and peptic ulcer agents. There is particular interest in their activity against several viruses such as HIV, herpes (HSV-1), and influenza. The classical method for benzimidazole synthesis is the coupling of ortho-arylenediamines with carboxylic acids or their derivatives, which requires strongly acidic conditions and high temperatures (>200°C). The other method is the oxidation of benzimidazoline intermediates that are generated from the condensation of ortho-arylenediamines and aldehydes.