N-Phosphinyl Phosphoramide-A Chiral Bronsted Acid Motif for the Direct Asymmetric N,O-Acetalization of Aldehydes

摘要

The advent of l,l'-binaphthalene-2,2'-diol (BINOL) phosphates as powerful Br0nsted acid catalysts heralded a new era in asymmetric organocatalysis. The recognition of the bifunctional mode of activation of these catalysts in reactions of imines with nucleophiles inspired organic chemists to design a variety of new asymmetric transformations.