Enantioselective Oxidative Cross-Coupling Reaction of 3-Indolylmethyl C-H Bonds with 1,3-Dicarbonyls Using a Chiral Lewis Acid-Bonded Nucleophile to Control Stereochemistry

摘要

Cross-coupling reactions using C-H activation have emerged as robust alternatives to conventional transformations for the creation of new C-C bonds. The enantioselective variants hold great potential in synthetic application, but continue to present formidable challenges. These reactions may be limited by the absence of binding sites in hydrocarbon compounds that enable the formation of a stereochemically defined transition state for achieving high enantioselectiv-ity. Furthermore, there are few examples of appropriate chiral ligands that tolerate the highly oxidizing conditions that are commonly used for C-H activation.