Methionine Can Favor DNA Platination by trans-Coordinated Platinum Antitumor Drugs

摘要

Cisplatin (cis-DDP) and its cis-coordinated analogues, carbo-platin and oxaliplatin, have been successfully used in the treatment of testicular and other solid tumors, but applications are restricted by side effects and intrinsic and acquired resistances. The discovery of trans-coordinated platinum complexes with antitumor activity provides a novel approach for cancer chemotherapy. Among several types of trans-platinum complexes, trans-[PtCl2{E-HN=C(OCH3)CH3}2] (trans-EE) raised particular interest because of its higher cytotoxicity than the cis isomer and its activity towards several ds-DDP-resistant tumor cells.