Interaction of Propionylated and Butyrylated Histone H3 Lysine Marks with Brd4 Bromodomains

摘要

The regulation of eukaryotic gene expression is determined by modifications in the chromatin structure. The highly variable pattern of modifications in the histone chains is described as the histone code. Two sets of histone proteins H2A, H2B, H3, and H4 form the octameric core of each nucleosome. Two turns of genomic DNA are wound around this octameric core to form the packaging of chromatin structures. Histone proteins are subject to a wide array of posttranslational modifications, including methylation, citrul-lination, acetylation, phosphorylation, ubiquitination, and sumoylation. These histone marks determine the state of chromatin dynamics and remodeling; the study of their specific imprint, which outlasts even cell division, is known as epigenetics.