Palladium-Catalyzed Hydroxylation of Aryl Halides under Ambient Conditions

摘要

Phenols are found in various natural products ranging from coal tar containing simple phenols to red wine possessing numerous colored polyphenols with antioxidant proper-ties. In organic synthesis the development of mild, general, and efficient methods for the preparation of phenols still constitutes a significant challenge. Considering the availability of starting materials, the direct nucleophilic substitution of a halogen atom in aryl halides is an appealing approach to the synthesis of substituted phenols. However, reactions of non-activated substrates typically proceed under harsh reaction conditions (200-350 °C).