Symmetry-Guided Design and Fluorous Synthesis of a Stable and Rapidly Excreted Imaging Tracer for ~(19)F MRI

摘要

~1H and ~(19)F are the most sensitive nuclei for nuclear magnetic resonance imaging (MRI), with the ~1H signal suited for collecting information about the body and the ~(19)F signal suited for collecting information about drugs in the body. Although ~(15)F MRI is only four years younger than ~1H MRI, it is not in clinical use. The progress of ~(19)F MRI has been stalled by the lack of suitable imaging agents. Current ~(19)F imaging agents are perfluorocarbon (PFC) emulsions and suffer severe shortcomings, including heterogeneity, instability, split ~(19)F signals, complex formulation procedure and, most importantly, excessive retention of the agent within organs for months or longer.