Long-Term Structural and Chemical Stability of DNA in Hydrated Ionic Liquids

摘要

There is much interest in the use of DNA as an advanced material. For example, DNA has been discussed as the "ultimate" material for molecular computing and there is much effort directed towards investigating this application. Recently, DNA has also been employed in templated chemical synthesis, nanomachines, and biosensors.The use of DNA as a biomaterial from a variety of readily available sources has gained importance in recent years, especially for the surface treatment of implanted materials. Since it is rich in phosphate groups it has a strong affinity for bone, and DNA has been modified for use as a bone-guiding scaffold by intercalating antibiotics between the stacked base pairs. The water-insoluble form of DNA also finds a range of other applications as a biomaterial.