Sequential and Modular Synthesis of Chiral 1,3-Diols with Two Stereogenic Centers: Access to All Four Stereoisomers by Combination of Organo-and Biocatalysis

摘要

Chiral 1,3-diols with two stereogenic centers are widely used as building blocks in the synthesis of pharmaceutically active compounds. In addition, numerous natural products possess a chiral 1,3-diol subunit. A further interesting application of chiral 1,3-diols is their transformation into chiral 1,3-bisphos-phanes, which are often used very successfully as enantio-merically pure ligands in asymmetric catalysis.