LiCl-Mediated Preparation of Functionalized Benzylic Indium(III)Halides and Highly Chemoselective Palladium-Catalyzed Cross-Coupling in a Protic Cosolvent

摘要

The development of palladium-catalyzed cross-coupling reactions has revolutionized the formation of carbon-carbon bonds.These coupling reactions have found many applications in natural product synthesis,material science,and medicinal chemistry.The Suzuki reaction,which involves organoboron compounds,has been widely used because of the ready availability of boronic esters and their excellent compatibility with many functional groups during the cross-coupling reaction.Typically,functional groups bearing acidic protons,ketones,and aldehydes are compatible with these coupling reactions.However,the low reactivity of boronic acids may require harsh reaction conditions or sophisticated ligand systems.Furthermore,some classes of boronic acid derivatives such as functionalized benzylic boronic acids are more difficult to prepare.