Synthesis of 1,3-Diamines Through Rhodium-Catalyzed C-H Insertion

摘要

Animation of C—H bonds continues to gain prominence as a general and selective method for chemical synthesis. Our research group has devised such processes using dimeric rhodium catalysts to enable the oxidative cyclization of carbamate, sulfamate, sulfonamide, urea, and guanidine substrates. The universal nature of this C-H insertion reaction may be further exploited with reactions of alkylsul-famides (Scheme 1). These unique starting materialsfurnish selectively six-membered-ring heterocyclic products that are of interest as medicinal agents and as precursors to substituted 1,3-diamines, the latter transformation having been made possible under mild reaction conditions by using chemistries described herein. The union of these methods represents a decided advance for C-H animation technology.