Functional Profiling, Identification, and Inhibition of Plasmepsins in Intraerythrocytic Malaria Parasites

摘要

Malaria is a global disease which affects 300-500 million people annually and kills 1-2 million. The most deadly form of the disease is caused by the pathogen Plasmodium falciparum. Currently, quinolines and antifolates are the most common antimalarial drugs. The cost of the drugs, as well as the emergence of multidrug resistance, has, however, become a major problem. Thus, there is a need for newer and ideally cheaper drags against this devastating disease.