Modular Synthesis of 1,2-Diamme Derivatives by Palladium-Catalyzed Aerobic Oxidative Cyclization of Allylic Sulfamides

摘要

Vicinal diamines are prevalent in biologically active molecules and as ligands for transition metals. Consequently, these structures have been the target of considerable synthetic effort.A number of novel palladium-catalyzed methods for the synthesis of diamines from alkenes and dienes have been reported recently. Limitations of these reactions with respect to substrate scope and identity of the stoichiometric oxidant (e.g., benzoquinone, PhI(OAc)2, and di-tert-butyldia-ziridinone), together with our interest in aerobic oxidation reactions, prompted us to consider whether analogous diamines could be prepared using O2 as the oxidant.