Enantioselective Synthesis of(+)-Chamaecypanone C:A Novel Microtubule Inhibitor

摘要

A number of bicyclo[2.2.2]octenone-containing natural products have been isolated from the heartwood of Chamaecy-paris obtusa var.formosana(Scheme 1), including the Diels-Alder(DA)adducts obtunone(1)and chamaecypa-none C(2), as well as the [4+2] dimer(+)-3.(+)-2 has been shown to exhibit potent cytotoxicity against several human cancer cells, including human oral epidermoid carcinoma(KB;IC_(50)= 190nM).