pH-Regulated Asymmetric Transfer Hydrogenation of Quinolines in Water

摘要

1,2,3,4-Tetrahydroquinolines exist as key structural elements in many natural products and have found broad commercial application. In particular, optically pure tetrahydroquinolines are commonly present in alkaloids and are required in pharmaceutical and agrochemical synthesis. Representative examples include the bioactive alkaloids (+)-galipinine and (-)-augustureine, and the antibacterial drug (S)-flume-quine.