Bronsted Acid Catalyzed Enantioselective Semipinacol Rearrangement for the Synthesis of Chiral Spiroethers

摘要

Spiroethers, which feature two fused rings joined by a single chiral oxo quaternary carbon center, are a versatile structural motif found in a variety of biologically significant natural products and pharmaceuticals. The effective synthesis of spiroethers, and particularly asymmetric syntheses are of great importance in modern synthetic chemistry.