Ruthenium-Catalyzed Regioselective Direct Alkylation of Arenes with Unactivated Alkyl Halides through C-H Bond Cleavage

摘要

Direct arylation of arenes by C-H bond cleavage, which is attractive because of its ecologically and economically benign nature, is an increasingly viable alternative to conventional cross-coupling reactions with stoichiometric amounts of organometallic reagents. However, while the development of stabilizing ligands allowed for the use of unactivated alkyl halides in traditional cross-coupling chemistry, generally applicable methodologies for intermolecular regioselective direct alkylations of arenes with alkyl halides by C-H bond cleavage have proven elusive.