Iridium-Catalyzed Reactions of Trifluoromethylated Compounds with Alkenes: A Csp3-H Bond Activation a to the Trifluoromethyl Group

摘要

Trifluoromethylated compounds play an important role in medicinal, agrochemical, and material science; therefore, exploitation of a general method for the synthesis of these compounds is highly desirable. Introduction of an α-trifluoromethyl group into the target molecule relies on either trifluoromethyl reagents or trifluoromethylated synthetic building blocks. It has been difficult to achieve carbon-carbon bond formation via α-trifluoromethyl carbanions because these carbanions and related organometallic species spontaneously release fluoride species to produce 1,1-difluoroolefins. This notorious decomposition of a-trifluoromethyl carbanions has hindered the development of this species for use in organic synthesis. Only few methods on the synthetic use of α-trifluoromethyl carbanions, under specific reaction conditions, have been reported.